Sen. Chuck Grassley (Iowa), who is the next Republican poised to chair the Judiciary Committee, will oppose Sonia Sotomayor for the Supreme Court, citing his regret over voting to confirm Justice David Souter, whom she would replace, the Des Moines Register reported Monday.

“I can say my vote for him is probably the only vote for 11 or 12 Supreme Court justices that has come back to haunt me from time to time … I think Judge Sotomayor’s very lukewarm answer that she gave me left me with the same pit in my stomach I had as a result of my vote for Souter,— the Register quoted Grassley as saying.

Grassley’s “no— vote on Sotomayor will mark the first time he has voted against a Supreme Court nominee in his nearly 30-year Senate career. Earlier Monday, Judiciary ranking member Jeff Sessions (R-Ala.) announced his opposition.

With Grassley’s announcement, it now appears Sotomayor will make it out of the Judiciary Committee with only one Republican vote — Sen. Lindsey Graham (R-S.C.).

Like most of his Republican colleagues that have come out against Sotomayor, Grassley argued that her answers during her confirmation hearings did not assuage his concerns about her previous statements and whether she would rule with impartiality.

“It seems to me answers to the questions she gave us about that don’t comport with what she actually said or adequate explanation overcoming doubts about her statements,— he said.