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American Crossroads is targeting six Senate races in a new round of television ads set to hit the airwaves today.

The Republican super PAC and its nonprofit arm, Crossroads GPS, has invested a combined $4.6 million in this buy, set to run statewide on broadcast and cable television in Missouri, Nebraska, Nevada, North Dakota, Ohio and Virginia. Except for Nevada, all of the seats are held by Democrats and considered top Republican pickup targets.

The spots include three attack ads from American Crossroads that are worth $2.6 million and critical of the Democratic nominees in Nebraska, Nevada and Virginia. The three issue ads from Crossroads GPS are running in Missouri, North Dakota and Ohio and focus on spending, debt and President Barack Obama’s health care law.

In Nebraska, American Crossroads charges former Sen. Bob Kerrey (D) with being “out of touch.”

In Nevada, the super PAC attempts to tar Rep. Shelley Berkley (D) as ethically challenged.

In Virginia, the group focuses on former Gov. Tim Kaine’s service as Obama’s first Democratic National Committee chairman.

The ads run by Crossroads GPS, while issues-based, employ visuals that could be interpreted as direct attacks on the Democrats running in those Senate races. The Missouri spot focuses on government spending and implies criticism of Sen. Claire McCaskill.

The Ohio ad notes that Sen. Sherrod Brown has been a strong supporter of Obama.

The spot in North Dakota attempts to tie former state Attorney General Heidi Heitkamp to the president’s health care law.

American Crossroads has spent a total of $5.7 million on television ads targeting Senate races since Thursday, when the super PAC went on the air in Indiana, Montana and New Mexico.

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